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LY 456236 hydrochloride

CAS No. 338736-46-2

LY 456236 hydrochloride( —— )

Catalog No. M33882 CAS No. 338736-46-2

LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 77 Get Quote
10MG 123 Get Quote
25MG 256 Get Quote
50MG 419 Get Quote
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Biological Information

  • Product Name
    LY 456236 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM.
  • Description
    LY456236 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC50 of 0.145 μM. LY456236 also inhibits EGFR with an IC50 of 0.91 μM.
  • In Vitro
    Cell Proliferation Assay Cell Line:OCCM-30 cells Concentration:2 μM Incubation Time:30 min, followed by 72 h incubation with DHPG (HY-12598A) Result:Reduced DHPG-stimulated OCCM-30 proliferation.
  • In Vivo
    Animal Model:DBA/2 mice and CD1 mice, seizure modelsDosage:3-100 mg/kgAdministration:IP, onceResult:Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice.Animal Model:Amygdala-kindled Sprague-Dawley rats Dosage:10, 30 and 60 mg/kg Administration:Oral, once Result:Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR | GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    338736-46-2
  • Formula Weight
    317.77
  • Molecular Formula
    C16H16ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (786.73 mM; Ultrasonic (<60°C)
  • SMILES
    Cl.COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ravikumar B, et al. Chemogenomic Analysis of the Druggable Kinome and Its Application to Repositioning and Lead Identification Studies. Cell Chem Biol. 2019 Nov 21;26(11):1608-1622.e6.?
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